Failure to Provoke the Local Shwartzman Reaction with Thrombin.
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چکیده
منابع مشابه
The Role of Vasoconstriction in the Local Shwartzman Reaction
The local Shwartzman reaction was provoked in the skin of the ear, hind leg, and costovertebral angle of the rabbit, as well as in the ventral abdominal skin. Certain adrenergic blocking drugs reduced the incidence of positive reactions when given prior to the provocative dose of bacterial polysaccharide. Epinephrine and other vasoconstrictor drugs administered intradermally into the prepared s...
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The development of a purpura-fulminans-like disorder which is a human equivalent of a local Shwartzman reaction in a woman with active chronic hepatitis is described. The cyclical appearance of blue-black, well circumscribed, haemorrhagic, acutely painful lesions in the buttocks, over the lateral aspects ofthe thighs, and on the arms suggested the diagnosis. Evidence of increased intravascular ...
متن کاملInhibition of the Generalized Shwartzman Reaction
The effect of hypofibrinogenemia on production of the generalized Shwartzman reaction (GSR) by the administration of Thorotrast (3 mI/kg) and Escherichia coil endotoxin (50 jzg) to rabbits was determined. Severe hypofibrinogenemia (fibrinogen less than 15 mg/ 100 ml) was produced by Arvin, a proteolytic coagulant from the venom of the Malayan pit viper, Agkistrodon rhodostoma. Development of th...
متن کاملShwartzman reaction in germfree rabbits.
The local Shwartzman reaction occurred in germfree rabbits which had no natural antibody to endotoxin and none or only a very small amount of immunoglobulin G. From the results it was concluded that the presence of natural antibody to endotoxin is not a prerequisite of the production of the local Shwartzman reaction by bacterial endotoxin.
متن کاملThe Prevention of the Generalized Shwartzman Reaction with Sodium Warfarin
Using intravenous sodium warfarin, rabbits were rendered hypoprothrombinemic and subjected to two intravenous injections of Shear's polysaccharide. None of the 9 animals surviving the required period of time developed bilateral renal cortical necrosis or histologic thrombi in the kidney, liver, spleen, or lungs. In a control group of 7 animals treated only with endotoxin, 6 developed bilateral ...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 1967
ISSN: 1535-3702,1535-3699
DOI: 10.3181/00379727-124-31841